Abstract
The effects of a chronic salbutamol intake (SAL, 12 mg/d during 3 weeks) on changes
in body composition, metabolic indices and performance during a 30-second Wingate
test were determined in 8 strength-trained male athletes (T) and 7 sedentary male
(UT) subjects, according to a double-blind, randomized, cross-over protocol. Blood
samples were collected both at rest, at the end of the test, and during passive recovery
(5 min, 10 min, 15 min) for leptin (at rest), and blood lactate measurements. No significant
changes in lean body mass, fat mass, and leptin were observed with SAL treatment in
either group during the trial. Peak power was significantly increased (p < 0.05) after
SAL intake in all subjects (T: 11.9 %; UT: 8.3 %) with a decrease in time to peak
power with SAL compared to placebo (PLA) (p < 0.05). There was no change in total
work performed and in fatigue indices with SAL compared to PLA. Blood lactate was
significantly increased after SAL vs. PLA during the recovery (p < 0.05) in all subjects.
The data demonstrate that the chronic administration of therapeutic levels of salbutamol
increases maximal anaerobic power in man, irrespective of the subjects' training status.
This study also rules out any implication of an anabolic effect in this improvement
in performance during supramaximal exercise. Further studies are necessary to clarify
the mechanisms involved.
Key words
β2-agonist - chronic intake - performance - supramaximal exercise - body composition
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Katia Collomp
Laboratoire de la Performance Motrice, Faculté du Sport et de l'Education Physique
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45062 Orléans Cedex 2
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